Multiple amino acid sensing inputs to mTORC1
نویسندگان
چکیده
منابع مشابه
Amino Acid Sensing by mTORC1: Intracellular Transporters Mark the Spot
Cell metabolism and growth are matched to nutrient availability via the amino-acid-regulated mechanistic target of rapamycin complex 1 (mTORC1). Transporters have emerged as important amino acid sensors controlling mTOR recruitment and activation at the surface of multiple intracellular compartments. Classically, this has involved late endosomes and lysosomes, but now, in a recent twist, also t...
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The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a major regulator of cell growth that responds to numerous environmental cues. A key input is amino acids, which act through the heterodimeric Rag GTPases (RagA or RagB bound to RagC or RagD) in order to promote the translocation of mTORC1 to the lysosomal surface, its site of activation. GATOR2 is a complex of unknown function th...
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Dysregulated metabolic signaling leading to increased mechanistic target of rapamycin complex 1 (mTORC1) activity has been associated with cancer, neurodegeneration, and an acceleration of the aging process [1]. Aging is characterized by a systemic decline of metabolic processes, including amino acid metabolism, that results in a steady accumulation of the nonproteinogenic amino acid homocystei...
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The mechanistic target of rapamycin (serine/threonine kinase) complex 1 (MTORC1) acts as a crucial regulator of cellular metabolism by integrating growth factor presence, energy and nutrient availability to coordinate anabolic and catabolic processes, and controls cell growth and proliferation. Amino acids are critical for MTORC1 activation, but the molecular mechanisms involved in sensing thei...
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The mammalian target of rapamycin complex 1 (mTORC1), which promotes cell growth, is regulated by specific nutrients such as the amino acid leucine. In this issue, Nicklin et al. (2009) describe a mechanism by which glutamine facilitates the uptake of leucine, leading to mTORC1 activation.
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ژورنال
عنوان ژورنال: Cell Research
سال: 2015
ISSN: 1001-0602,1748-7838
DOI: 10.1038/cr.2015.146